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Prevents a spell or ability from resolving.

Removes threats by exiling rather than destroying — bypasses indestructible and death triggers.

Removes any nonland permanent — the Vindicate, Beast Within, Generous Gift category. Most flexible single-target removal.

Specifically removes planeswalkers.

Answers an opponent's threat by destroying, exiling, bouncing, or otherwise removing a permanent or spell.

Answers an opponent's threat by destroying, exiling, bouncing, or otherwise removing a permanent or spell.

Tax or prevent spellcasting — Rule of Law, Thalia, Sphere of Resistance.